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KMID : 0357920010350020115
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Korean Journal of Pathology
2001 Volume.35 No. 2 p.115 ~ p.122
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The Expression of Transforming Growth Factor-β1 and Its Signaling Receptors in HumanColorectal Carcinoma
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Kim Gyeong-Seon
Kim Ju-Hun
Moon Woo-Sung
Chung Myoung-Ja
Lee Dong-Geun
Kang Myoung-Jae
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Abstract
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Background: Resistance to the potent growth inhibitory effects of TGF-β (transforming growth factor-β) is a characteristic of many malignancies. TGF-β insensitivity has been attributed to alterations in the number and function of the TGF-β receptors as well as disturbances of downstream signal transduction. The aim of this study was to examine the expression of TGF-β1 and its receptors in human colorectal cancer tissue and determine its relationship with cancer growth and with prognostic factors.
Methods: Immunohistochemical staining of TGF-β1, TGF-βRI, and TGF-βRII was performed on 20 human colorectal adenomas, 30 carcinomas and 10 normal mucosas as a control.
Results: The staining indices of TGF-β1, TGF-βRI, and TGF-βRII increased in adenomas and carcinomas compared with normal mucosas and adenomas, respectively. In adenomas the staining index of TGF-β1 significantly increased with the severity of atypism. The staining index of TGF-βRII increased in the carcinomas in the right colon and rectum, compared with those in the left colon.
Conclusions: The enhanced expression of TGF-β1, TGF-βRI and II in the colorectal carcinoma suggests an important role of colorectal carcinogenesis and tumor progression.
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KEYWORD
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Colorectal neoplasms, Transforming growth factor beta, Receptors, Immunohistochemistry
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